An injectable, shear-thinning biomaterial that enables deep neurovascular occlusion
Patients undergoing surgical resection of hypervascular brain tumors are at risk of significant blood loss, making surgery time-consuming and technically difficult. Embolization is an increasingly used minimally-invasive technique in neurovascular interventions to block blood flow to target vessels. Pre-operative tumor embolization is reported to improve patient outcomes; however, there remains a need for a next-generation material that provides vessel occlusion and deep penetration into the vessel bed.
AMI-002 is a solvent-free, shear-thinning biomaterial developed using an iterative cycle of extensive bench characterization and preclinical studies to understand the properties required for optimal performance. Its shear-thinning property enables deep penetration of target vessels while minimizing the risk of non-target embolization. Within minutes, the biomaterial cures into an elastomeric solid providing a complete and durable occlusion.